| AL BATTING AVERAGE | AVG | |
 Joe Mauer |
1. Joe Mauer, MIN | .366 |
| 2. Ichiro Suzuki, SEA | .362 | |
| 3. Jason Bartlett, TAM | .334 | |
| 4. Miguel Cabrera, DET | .329 | |
| 5. Michael Young, TEX | .325 | |
| Complete Leaders | ||
| NL BATTING AVERAGE | AVG | |
 Hanley Ramirez |
1. Hanley Ramirez, FLA | .343 |
| 2. Pablo Sandoval, SFO | .332 | |
| 3. David Wright, NYM | .327 | |
| 4. Albert Pujols, STL | .326 | |
| 5. Ryan Braun, MIL | .320 | |
| Complete Leaders | ||
| AL HOME RUNS | HR | |
 Carlos Pena |
1. Carlos Pena, TAM | 28 |
| 2. Mark Teixeira, NYY | 28 | |
| 3. Justin Morneau, MIN | 28 | |
| 4. Aaron Hill, TOR | 26 | |
| 5. Russell Branyan, SEA | 25 | |
| Complete Leaders | ||
| NL HOME RUNS | HR | |
 Albert Pujols |
1. Albert Pujols, STL | 36 |
| 2. Mark Reynolds, ARI | 35 | |
| 3. Adam Dunn, WAS | 29 | |
| 4. Adrian Gonzalez, SDG | 29 | |
| 5. Prince Fielder, MIL | 27 | |
| Complete Leaders | ||
| AL RUNS BATTED IN | RBI | |
 Justin Morneau |
1. Justin Morneau, MIN | 91 |
| 2. Evan Longoria, TAM | 83 | |
| 3. Mark Teixeira, NYY | 82 | |
| 4. Nick Markakis, BAL | 78 | |
| 5. Bobby Abreu, LAA | 77 | |
| Complete Leaders | ||
| NL RUNS BATTED IN | RBI | |
|
Albert Pujols |
1. Albert Pujols, STL | 100 |
| 2. Prince Fielder, MIL | 98 | |
| 3. Adam Dunn, WAS | 82 | |
| 4. Ryan Howard, PHI | 79 | |
| 5. Ryan Braun, MIL | 79 | |
| Complete Leaders | ||
| AL WINS | W | |
 Josh Beckett |
1. Josh Beckett, BOS | 13 |
| 2. CC Sabathia, NYY | 12 | |
| 3. Justin Verlander, DET | 12 | |
| 4. Felix Hernandez, SEA | 12 | |
| 5. Jered Weaver, LAA | 12 | |
| Complete Leaders | ||
| NL WINS | W | |
 Adam Wainwright |
1. Adam Wainwright, STL | 13 |
| 2. Tim Lincecum, SFO | 12 | |
| 3. Jason Marquis, COL | 12 | |
| 4. Matt Cain, SFO | 12 | |
| 5. Johan Santana, NYM | 12 | |
| Complete Leaders | ||
| AL EARNED RUN AVERAGE | ERA | |
 Zack Greinke |
1. Zack Greinke, KAN | 2.43 |
| 2. Edwin Jackson, DET | 2.62 | |
| 3. Roy Halladay, TOR | 2.75 | |
| 4. Felix Hernandez, SEA | 2.84 | |
| 5. Jarrod Washburn, DET/SEA | 2.93 | |
| Complete Leaders | ||
| NL EARNED RUN AVERAGE | ERA | |
 Tim Lincecum |
1. Tim Lincecum, SFO | 2.20 |
| 2. Matt Cain, SFO | 2.25 | |
| 3. Chris Carpenter, STL | 2.26 | |
| 4. Dan Haren, ARI | 2.57 | |
| 5. Wandy Rodriguez, HOU | 2.63 | |
| Complete Leaders | ||
| AL SAVES | SV | |
 Mariano Rivera |
1. Mariano Rivera, NYY | 31 |
| 2. Brian Fuentes, LAA | 31 | |
| 3. Joe Nathan, MIN | 29 | |
| 4. Jonathan Papelbon, BOS | 27 | |
| 5. David Aardsma, SEA | 26 | |
| Complete Leaders | ||
| NL SAVES | SV | |
 Heath Bell |
1. Heath Bell, SDG | 28 |
| 2. Huston Street, COL | 28 | |
| 3. Brian Wilson, SFO | 28 | |
| 4. Ryan Franklin, STL | 26 | |
| 5. Trevor Hoffman, MIL | 25 | |
| Complete Leader | ||