- Chicago White Sox starter Chris Sale was placed on the 15-day DL with a flexor muscle strain in his left arm, the team announced. The Sox recalled Charlie Leesman from Triple-A Charlotte to replace Sale, who was 3-0 with a 2.30 ERA in four starts prior to his injury.
- The San Francisco Giants placed left-hander David Huff on the 15-day DL with a left quad strain, the team announced, while recalling outfielder Juan Perez from Triple-A Fresno. Huff had allowed three runs over seven innings this season, while Perez batted .421 in 19 at-bats at Triple-A.
- The New York Yankees activated closer David Robertson off the 15-day DL and outrighted left-hander Cesar Cabral to Triple-A Scranton/Wilkes-Barre, according to MLB.com's Bryan Hoch.
- The Houston Astros recalled right-hander Collin McHugh from Triple-A Oklahoma City, according to a team announcement. In a corresponding move, the Astros loaned first baseman Japhet Amador to the Diablos Rojos del Mexico of the Mexican Baseball League. McHugh struck out 12 batters over 6.2 scoreless innings in his start on Tuesday.
- The Washington Nationals optioned Xavier Cedeno to Triple-A Syracuse, the team announced, recalling Aaron Barrett from Triple-A to fill the vacant roster spot.
- The Toronto Blue Jays claimed Darin Mastroianni off waivers from the Minnesota Twins, according to a team announcement. The Jays optioned Mastroianni to Triple-A Buffalo, while also designating center fielder Kenny Wilson for assignment.
- The Baltimore Orioles designated left fielder Steve Pearce for assignment, the team announced, while recalling T.J. McFarland from Triple-A Norfolk.
- The Minnesota Twins activated left fielder Sam Fuld, per a team announcement, while officially releasing Jason Bartlett, who announced his retirement on Friday.
- The Texas Rangers designated right-hander Hector Noesi for assignment, recalling right-hander Nick Martinez from Double-A Frisco, as announced by Rangers Executive VP of Communications John Blake.
- Starting pitcher Mike Minor could make his first start of the season for the Atlanta Braves this weekend. According to the Atlanta Journal-Constitution's Carroll Rogers, Minor will gauge his progress based on the bullpen he threw on Tuesday, which apparently went well, as the Journal-Constitution's David O'Brien reported the Braves tentatively plan to start Minor on Saturday.
- The Atlanta Braves traded shortstop Tyler Greene to the San Diego Padres, according the Atlanta Journal-Constitution's David O'Brien. A .224 hitter who has yet to appear in the majors this season, Greene provides some infield depth for Triple-A El Paso, which is currently dealing with infielder Ryan Jackson's recently sprained wrist.
- Los Angeles Angels slugger Albert Pujols hit a pair of homers to become the 26th player to reach 500 long balls in his career. The two-homer day also gave Pujols a big-league leading eight long balls on the season and helped the Angels to a 7-2 victory.
- Miami Marlins ace Jose Fernandez pitched a gem, limiting the Braves to three hits over eight dominant innings as he struck out 14 in a 1-0 Miami victory.
- For the second time in as many starts, Cincinnati Reds starter Johnny Cueto allowed just three hits in a complete-game victory. Cueto surrendered one run, lowering his ERA to 1.38 on the season and giving the Reds a 4-1 victory.